Pathways
Fas Signaling
Description:
Fas (also called Apo1 or CD95) is a death domain-containing member of the TNFR (Tumor Necrosis Factor Receptor) superfamily. It has a central role in the physiological regulation of Programmed Cell Death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Although the FasL (Fas Ligand)-Fas system has been appreciated mainly with respect to its death-inducing function, it also transduces proliferative and activating signals through pathways that are still poorly defined. The F...
References:
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Fas-Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis.
Front Immunol. 2016 Sep 27;7:382. eCollection 2016. Review. -
Targeting the Fas/FasL system in Rheumatoid Arthritis therapy: Promising or risky?
Cytokine. 2015 Oct;75(2):228-33. doi: 10.1016/j.cyto.2014.10.004. Epub 2014 Dec 4. Review. -
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.
Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a008730. doi: 10.1101/cshperspect.a008730. Review. -
Role of apoptosis in disease.
Aging (Albany NY). 2012 May;4(5):330-49. Review.
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