Fas (also called Apo1 or CD95) is a death domain-containing member of the TNFR (Tumor Necrosis Factor Receptor) superfamily. It has a central role in the physiological regulation of Programmed Cell Death and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Although the FasL (Fas Ligand)-Fas system has been appreciated mainly with respect to its death-inducing function, it also tran[...]
Kim JH, Park ME, Nikapitiya C, Kim TH, Uddin MB, Lee HC, Kim E, Ma JY, Jung JU, Kim CJ, Lee JS. PLoS Pathog. 2017 May 22;13(5):e1006398. doi: 10.1371/journal.ppat.1006398. eCollection 2017 May. Erratum in: PLoS Pathog. 2018 Sep 21;14(9):e1007302.