Pathways
Fc-EpsilonRI Pathway
Description:
FcεRI is constitutively expressed on mast cells as a tetrameric receptor composed of the IgE-binding α chain, the membrane-tetraspanning β chain, and the disulfide-linked homodimer of the γ chains. The level of expression of the FcεRI on the mast cell surface can be influenced by several factors, such as IgE availability or IgE binding. Antigen (Ag) ligation of IgE-bound FcεRI initiates phosphorylation cascades that cause profound morphological and transcriptional modifications. As FcεRI lacks ...
References:
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Mast cell activation: a complex interplay of positive and negative signaling pathways.
Eur J Immunol. 2014 Sep; 44(9):2558-66. -
New developments in FcepsilonRI regulation, function and inhibition.
Nat Rev Immunol. 2007 May; 7(5):365-78. -
Progress in the study of allergic disease drugs targeting on IgE/FcepsilonRI signaling pathway.
Yao Xue Xue Bao. 2011 Oct;46(10):1161-6. -
The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase.
J Biol Chem. 2003 Nov 28; 278(48):48474-84.
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