Pathways
Fc-GammaR-Mediated Phagocytosis in Macrophages
Description:
Phagocytosis, defined as the cellular uptake of particulates (>0.5 m) within a plasma-membrane envelope, is closely related to and partly overlaps the endocytosis of soluble ligands by fluid-phase macropinocytic and receptor pathways. The uptake of exogenous particles (heterophagy) has features in common with autophagy, an endogenous process of sequestration and lysosomal disposal of damaged intracellular organelles. There is a spectrum of uptake mechanisms depending on the particle size, multiplicity of receptor-ligand interact...
References:
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Phagocytosis: A Fundamental Process in Immunity.
Biomed Res Int. 2017; 2017:9042851. doi: 10.1155/2017/9042851. Epub 2017 Jun 12. Review. -
Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaRphagocytosis by prostaglandin E2 in alveolar macrophages.
J Immunol. 2007 Dec 15; 179(12):8350-6. -
Phagocytosis: An Immunobiologic Process.
Immunity. 2016 Mar 15; 44(3):463-475. doi: 10.1016/j.immuni.2016.02.026. Review. -
Contributions of proteomics to understanding phagosome maturation.
Cell Microbiol. 2008 Jul; 10(7):1405-12. doi: 10.1111/j.1462-5822.2008.01140.x. Epub 2008 Mar 10. Review.
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