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Fc-GammaR Pathway


Fcγ receptors are a family of glycoproteins expressed on the membrane of immune cells, and capable of binding the Fc portion of IgG antibody molecules. These receptors bind to various IgG subclasses with different affinities, and when crosslinked by multivalent antigen-antibody complexes, can induce different cellular responses. In humans, several activating receptors (FcγRI/CD64, FcγRIIa/CD32a and FcγRIIIa/CD16a), one inhibitory receptor (FcγRIIb/CD32b), and one glycosylphosphatidylinositol (GPI)-linked...




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