Pathways
Fc-GammaR Pathway
Description:
Fcγ receptors are a family of glycoproteins expressed on the membrane of immune cells, and capable of binding the Fc portion of IgG antibody molecules. These receptors bind to various IgG subclasses with different affinities, and when crosslinked by multivalent antigen-antibody complexes, can induce different cellular responses. In humans, several activating receptors (FcγRI/CD64, FcγRIIa/CD32a and FcγRIIIa/CD16a), one inhibitory receptor (FcγRIIb/CD32b), and one glycosylphosphatidylinositol (GPI)-linked...
References:
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Fcγ Receptor Heterogeneity in Leukocyte Functional Responses.
Front Immunol. 2017 Mar 20; 8:280. doi: 10.3389/fimmu.2017.00280. eCollection 2017. Review. -
Fcγ receptor pathways during active and passive immunization.
Immunol Rev. 2015 Nov; 268(1):88-103. doi: 10.1111/imr.12343. Review. -
Diverse novel functions of neutrophils in immunity, inflammation, and beyond.
J Exp Med. 2013 Jul 1; 210(7):1283-99. doi: 10.1084/jem.20122220. Review. -
Neutrophils in Cancer: Two Sides of the Same Coin.
J Immunol Res. 2015; 2015:983698. doi: 10.1155/2015/983698. Epub 2015 Dec 24. Review.
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