Pathways
FLT3 Signaling
Description:
FLT3 (Fms-like Tyrosine Kinase-3), also known as FLK2 (Fetal Liver Kinase-2) and STK1 (human Stem Cell Kinase-1) was originally isolated as a hematopoietic progenitor cell-specific kinase, and belongs to the Class-III RTK (Receptor Tyrosine Kinase) family to which c-Fms, c-Kit, and the PDGFR (Platelet Derived Growth Factor Receptor) also belong (Ref.1). Normal expression of FLT3 is restricted to haemopoietic progenitor cells in the bone marrow, thymus and lymph nodes, but is also found on other tissues such as placenta, brain, c...
References:
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An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment.
Oncol Rev. 2012 Apr 17;6(1):e8. doi: 10.4081/oncol.2012.e8. eCollection 2012 Mar 5. Review. -
High expression of FLT3 is a risk factor in leukemia.
Mol Med Rep. 2018 Feb;17(2):2885-2892. doi: 10.3892/mmr.2017.8232. Epub 2017 Dec 8. -
Integrated analysis of miRNA and mRNA during differentiation of human CD34+ cells delineates the regulatory roles of microRNA in hematopoiesis.
Exp Hematol. 2014 Jan;42(1):14-27.e1-2. doi: 10.1016/j.exphem.2013.10.003. Epub 2013 Oct 16. -
Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia.
Stem Cell Investig. 2017 Jun 2;4:48. doi: 10.21037/sci.2017.05.04. eCollection 2017. Review.
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