Pathways
FMLP Pathway
Description:
Neutrophils play an important role in the host defense by invading microbial pathogens. Upon infection neutrophils become activated through interaction with chemo attractants and cytokines. These ligands bind to a variety of cell surface receptors, including heterotrimeric GPCR (G-Protein Coupled Receptors) for fMLP (N-formyl-Met-Leu-Phe) and PAF (Platelet Activating Factor), and tyrosine kinase-associated receptors for GMCSF (Granulocyte-Macrophage Colony Stimulating Factor). Receptor activation triggers intracellular sig...
References:
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Neutrophil cell surface receptors and their intracellular signal transduction pathways.
Int Immunopharmacol. 2013 Nov;17(3):638-50. doi: 10.1016/j.intimp.2013.06.034. Epub 2013 Aug 30. Review. -
Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking.
J Biol Chem. 2018 Aug 17;293(33):12690-12702. doi: 10.1074/jbc.RA118.002404. Epub 2018 Jun 21. -
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.
Front Cell Infect Microbiol. 2017 Aug 25;7:373. doi: 10.3389/fcimb.2017.00373. eCollection 2017. Review. -
The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation.
J Biol Chem. 2000 Aug 25; 275(34): 26225-32.
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