Pathways
Frizzled-PCP Pathway in D. melanogaster
Description:
Epithelia are polarized along the apical–basal axis in order to allow for directional transport of proteins within a cell or secretion of factors into. In addition, most epithelia are also polarized within the epithelial plane. The latter polarization is called epithelial PCP (Planar Cell Polarity) or tissue polarity. Planar polarization provides a cell not only with positional information but also directional (vectorial) information and correct PCP is a prerequisite for the formation of many organs. PCP, however, is be...
References:
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Planar cell polarity signaling in the Drosophila eye.
Curr Top Dev Biol. 2010;93:189-227. doi: 10.1016/B978-0-12-385044-7.00007-2. Review. -
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
Curr Top Dev Biol. 2016;117:75-91. doi: 10.1016/bs.ctdb.2015.11.027. Epub 2016 Jan 7. Review. -
DEEP Insights through the DEP Domain.
Structure. 2010 Oct 13;18(10):1223-5. doi: 10.1016/j.str.2010.09.007. -
Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye.
Fly (Austin). 2011 Apr-Jun;5(2):88-101. Epub 2011 Apr 1.
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