Pathways
G12-G13 in Cellular Signaling
Description:
The G12 subfamily of heterotrimeric G proteins, comprised of the Alpha-subunits G-Alpha12 and G-Alpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. Activated G-Alpha12 and G-Alpha13 have a molecular weight of 43,000 kDa and they show more than 66% amino acid identity. They stimulate mitogenic signaling pathways leading to the oncogenic transformation of fibroblast cell lines. Recent analyses have indicated that G-Alpha12 and G-Alpha13 re...
References:
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Rho GTPases in platelet function.
J Thromb Haemost. 2013 Jan;11(1):35-46. doi: 10.1111/jth.12051. Review. Erratum in: J Thromb Haemost. 2013 Jun;11(6):1209. -
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
J Biol Chem. 2013 Apr 26;288(17):12232-43. doi: 10.1074/jbc.M112.428599. Epub 2013 Mar 6. -
Probing heterotrimeric G protein activation: applications to biased ligands.
Curr Pharm Des. 2012;18(2):128-44. Review. -
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.
J Biochem. 2011 Oct;150(4):357-69. doi: 10.1093/jb/mvr105. Epub 2011 Aug 26. Review.
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