Pathways
G2-M Phase Transition
Description:
The cellular responses to DNA damage induced by ionizing radiation include activation of cell cycle checkpoints that delay progression of cells through the cell cycle. Ionizing radiation-induced checkpoints are active at the transition from the G1-phase to the S-phase, in the S-phase, and at the transition from the G2-phase to mitosis (G2/M). The surveillance mechanisms responsible for initiating these checkpoints appear to facilitate maintenance of the integrity of the genome, presumably because they ensure that damaged DNA ...
References:
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Understanding the limitations of radiation-induced cell cycle checkpoints.
Crit Rev Biochem Mol Biol. 2011 Aug;46(4):271-83. doi: 10.3109/10409238.2011.575764. Epub 2011 Apr 27. Review. -
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.
Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849. Epub 2012 Sep 12. -
The kinetics of G2 and M transitions regulated by B cyclins.
PLoS One. 2013 Dec 4;8(12):e80861. doi: 10.1371/journal.pone.0080861. eCollection 2013. -
Signaling pathways that regulate cell division.
Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a005942. doi: 10.1101/cshperspect.a005942. Review.
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