Pathways
GADD45 Pathway
Description:
Genotoxic stress is an important and ubiquitous type of stress that cells are inevitably exposed to over the life span of an organism. Many potentially damaging agents both from the environment and from endogenous processes involving activated oxygen species and other reactive agents can damage the DNA in cells (Ref.1). GADD45 induction by BRCA1 leads to programmed cell death through the JNK pathway via interaction with the upstream kinase MTK1/MEKK4. JNK has been shown to be involved in the induction of apoptosis after genot...
References:
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The involvement of WT1 in the regulation of GADD45a in response to genotoxic stress.
Mutagenesis. 2013 Jul;28(4):393-9. doi: 10.1093/mutage/get015. Epub 2013 Mar 9. -
GADD45 proteins: central players in tumorigenesis.
Curr Mol Med. 2012 Jun;12(5):634-51. Review. -
Census and evaluation of p53 target genes.
Oncogene. 2017 Jul 13;36(28):3943-3956. doi: 10.1038/onc.2016.502. Epub 2017 Mar 13. Review. -
CIL-102- Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.
PLoS One. 2017 Jan 9;12(1):e0168989. doi: 10.1371/journal.pone.0168989. eCollection 2017.
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