Pathways
GDNF-Family Ligands and Receptor Interactions
Description:
Neurotrophic factors are a broad set of peptide growth factors that tightly regulate many critical aspects of the ontogeny of neurons, such as the number of neurons in a given population, neurite branching and synaptogenesis, adult synaptic plasticity and maturation of electrophysiological properties. Neurotrophic factors include Neurotrophins, Neurokines and GDNF (Glial-cell-line-derived Neurotrophic Factor) family ligands (GFLs). GDNF family, consisting of GDNF, NRTN (Neurturin), ARTN (Artemin) and PSPN (Persephin) are dist...
References:
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GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance.
Int J Mol Sci. 2018 Apr 4;19(4). pii: E1078. doi: 10.3390/ijms19041078. Review. -
The GDNF Family: A Role in Cancer?
Neoplasia. 2018 Jan;20(1):99-117. doi: 10.1016/j.neo.2017.10.010. Epub 2017 Dec 12. Review. -
Physiological Signaling and Structure of the HGF Receptor MET.
Biomedicines. 2014 Dec 31;3(1):1-31. doi: 10.3390/biomedicines3010001. Review. -
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease.
FEBS Lett. 2015 Dec 21;589(24 Pt A):3760-72. doi: 10.1016/j.febslet.2015.11.006. Epub 2015 Nov 7. Review.
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