Pathways
Germ Cell-Sertoli Cell Junction Dynamics
Description:
Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. Germ cell movement within the epithelium is vital because germ cells, if induced to release into the tubule lumen prematurely, will be unable to fertilize the ovum. On the other hand, if germ cells are forced to remain attached to the seminiferous epithelium for a period of time longer than necessary to complete their development, they will degenerate and eventually be phagocytosed by Sertoli cells and for t...
References:
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The Mammalian Blood-Testis Barrier: Its Biology and Regulation.
Endocr Rev. 2015 Oct;36(5):564-91. doi: 10.1210/er.2014-1101. Epub 2015 Sep 10. Review. Erratum in: Endocr Rev. 2015 Dec;36(6):681. Endocr Rev. 2016 Feb;2016(1):43. -
Germ cell transport across the seminiferous epithelium during spermatogenesis.
Physiology (Bethesda). 2014 Jul;29(4):286-98. doi: 10.1152/physiol.00001.2014. Review. -
Sertoli-germ cell junctions in the testis: a review of recent data.
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1593-605. doi: 10.1098/rstb.2009.0251. Review. -
Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.
Int Rev Cell Mol Biol. 2013;301:291-358. doi: 10.1016/B978-0-12-407704-1.00006-3. Review.
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