Pathways
Glioma Invasiveness
Description:
Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). Transformed glial cells share the common attributes of the invasion process, including cell adhesion to ECM (Extracellular Matrix) compo...
References:
-
Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models.
Int J Mol Sci. 2018 Jan 4;19(1). pii: E147. doi: 10.3390/ijms19010147. Review. -
CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility.
Mol Cancer Res. 2014 Oct;12(10):1416-29. doi: 10.1158/1541-7786.MCR-13-0629. Epub 2014 Jun 24. -
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.
Front Immunol. 2015 May 6;6:201. doi: 10.3389/fimmu.2015.00201. eCollection 2015. Review. -
Extracellular matrix degradation and remodeling in development and disease.
Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a005058. doi: 10.1101/cshperspect.a005058. Review.
You can view details of this pathway by subscribing:
9853 Pacific Heights Blvd.
Suite D., San Diego, CA 92121, USA
Tel: 858-224-2869
Fax: 858-205-1192
info@proteinlounge.com
Databases
Tools
Institutional License
Need our databases and tools to be availed by your whole university or institute? We recommend signing up for our Site License.
To set up a license, please contact: info@proteinlounge.com
Copyright © Protein Lounge Inc.
Terms & Conditions