Glioma Invasiveness

Description:

Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). Transformed glial cells share the co[...]

References:

Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models.
Manini I, Caponnetto F, Bartolini A, Ius T, Mariuzzi L, Di Loreto C, Beltrami AP, Cesselli D.
Int J Mol Sci. 2018 Jan 4;19(1). pii: E147. doi: 10.3390/ijms19010147. Review.
CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility.
Kim Y, Kumar S.
Mol Cancer Res. 2014 Oct;12(10):1416-29. doi: 10.1158/1541-7786.MCR-13-0629. Epub 2014 Jun 24.
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.
Misra S, Hascall VC, Markwald RR, Ghatak S.
Front Immunol. 2015 May 6;6:201. doi: 10.3389/fimmu.2015.00201. eCollection 2015. Review.
Extracellular matrix degradation and remodeling in development and disease.
Lu P, Takai K, Weaver VM, Werb Z.
Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a005058. doi: 10.1101/cshperspect.a005058. Review.
Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas.
Ramachandran RK, Sørensen MD, Aaberg-Jessen C, Hermansen SK, Kristensen BW.
PLoS One. 2017 Feb 24;12(2):e0172234. doi: 10.1371/journal.pone.0172234. eCollection 2017.
Pilocytic astrocytoma: pathology, molecular mechanisms and markers.
Collins VP, Jones DT, Giannini C.
Acta Neuropathol. 2015 Jun;129(6):775-88. doi: 10.1007/s00401-015-1410-7. Epub 2015 Mar 20. Review.
Mechanisms of glioma-associated neovascularization.
Hardee ME, Zagzag D.
Am J Pathol. 2012 Oct;181(4):1126-41. doi: 10.1016/j.ajpath.2012.06.030. Epub 2012 Aug 2. Review.
Developmentally regulated signaling pathways in glioma invasion.
Mehta S, Lo Cascio C.
Cell Mol Life Sci. 2018 Feb;75(3):385-402. doi: 10.1007/s00018-017-2608-8. Epub 2017 Aug 18. Review.

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Pathways

Glioma Invasiveness

Description:

References:

Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models.

CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility.

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer.

Extracellular matrix degradation and remodeling in development and disease.

Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas.

Pilocytic astrocytoma: pathology, molecular mechanisms and markers.

Mechanisms of glioma-associated neovascularization.

Developmentally regulated signaling pathways in glioma invasion.

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Glioma Invasiveness

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References:

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