Pathways
Glucocorticoid Receptor Signaling
Description:
Our bones get more brittle with increasing age, and to add insult to injury, the most effective therapy for another problem that is associated with getting older, rheumatoid arthritis, often adds to the problem by causing bone resorption. The Glucocorticoid steroids, are the best available anti-inflammatories, and are used widely in the treatment of arthritis, as well as other inflammatory conditions such as dermatitis and autoimmune diseases. The Glucocorticoids, secreted by the Adrenal Cortex are powerful anti-inflammatory com...
References:
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Glucocorticoid receptor signaling in health and disease.
Trends Pharmacol Sci. 2013 Sep;34(9):518-30. doi: 10.1016/j.tips.2013.07.003. Epub 2013 Aug 14. Review. -
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
J Allergy Clin Immunol. 2013 Nov;132(5):1033-44. doi: 10.1016/j.jaci.2013.09.007. Epub 2013 Sep 29. Review. -
One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids.
J Allergy Clin Immunol. 2013 Nov;132(5):1033-44. doi: 10.1016/j.jaci.2013.09.007. Epub 2013 Sep 29. Review. -
The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation.
Br J Pharmacol. 2012 May;166(2):637-49. doi: 10.1111/j.1476-5381.2011.01783.x.
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