Glutathione Metabolism in C. albicans

Description:

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. F...

References:

Glutathione: overview of its protective roles, measurement, and biosynthesis.
Forman HJ, Zhang H, Rinna A.
Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12.
The spectrum of fungi that infects humans.
Köhler JR, Casadevall A, Perfect J.
Cold Spring Harb Perspect Med. 2014 Nov 3;5(1):a019273.
The response to heat shock and oxidative stress in Saccharomyces cerevisiae.
Morano KA, Grant CM, Moye-Rowley WS.
Genetics. 2012 Apr;190(4):1157-95.
Large conformational changes in the catalytic cycle of glutathione synthase.
Gogos A, Shapiro L.
Structure (Camb). 2002 Dec; 10(12):1669-76

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Pathways

Glutathione Metabolism in C. albicans

Description:

References:

Glutathione: overview of its protective roles, measurement, and biosynthesis.

The spectrum of fungi that infects humans.

The response to heat shock and oxidative stress in Saccharomyces cerevisiae.

Large conformational changes in the catalytic cycle of glutathione synthase.

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Tools

Institutional License

Pathways

Glutathione Metabolism in C. albicans

Description:

References:

Glutathione: overview of its protective roles, measurement, and biosynthesis.

The spectrum of fungi that infects humans.

The response to heat shock and oxidative stress in Saccharomyces cerevisiae.

Large conformational changes in the catalytic cycle of glutathione synthase.

Databases

Tools

Institutional License

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