Pathways
Glutathione Metabolism in E. coli O157 Sakai
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. It is homeostatically controlled, both inside the cell and outside and often attains millimolar levels inside cells, which makes it one of the most highly concentra...
References:
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Genomic diversity of enterohemorrhagic Escherichia coli O157 revealed by whole genome PCR scanning.
Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):17043-8. -
Massive outbreak of Escherichia coli O157:H7 infection in schoolchildren in Sakai City, Japan, associated with consumption of white radish sprouts.
Am J Epidemiol. 1999 Oct 15; 150(8):787-96. -
Interactions between biosynthesis, compartmentation and transport in the control of glutathione homeostasis and signalling.
J Exp Bot. 2002 May; 53(372):1283-304 -
Regulation of aminopeptidase N (EC 3.4.11.2; APN; CD13) by interferon-gamma on the HL-60 cell line.
Life Sci. 2005 Apr 22; 76(23):2681-97
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