Pathways
Glutathione Metabolism in C. elegans
Description:
Glutathione is an intracellular low-molecular-mass thiol which serves as a major cellular line of defense against oxidative stimuli at several levels. Glutathione plays important roles in antioxidant defense, nutrient metabolism, and regulation of cellular. Glutathione deficiency contributes to oxidative stress leading to aging and the pathogenesis of many diseases (including kwashiorkor, seizure, Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, hea...
References:
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The glutathione system and the related thiol network in Caenorhabditis elegans.
Redox Biol. 2019 Jun;24:101171. doi: 10.1016/j.redox.2019.101171. Epub 2019 Mar 16. Review. -
Quantification of Glutathione in Caenorhabditis elegans.
Curr Protoc Toxicol. 2015;64:6.18.1-6. doi: 10.1002/0471140856.tx0618s64. -
Non-linear impact of glutathione depletion on C. elegans life span and stress resistance.
Redox Biol. 2017 Apr;11:502-515. doi: 10.1016/j.redox.2016.12.003. Epub 2016 Dec 6. -
A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P.
J Biol Chem. 2002 Oct 25;277(43):41254-8. Epub 2002 Aug 15.
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