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Glutathione Metabolism in S. flexneri 2457T


Shigella is a Gram-negative, non-sporulating, facultative anaerobic bacterium that causes Dysentery or Shigellosis in man. Shigella is highly invasive in the colon and the rectum, and is able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. The strain S. flexneri 2457T harbors four plasmids, which remains to be completed. Glutathione metabolism in Shigella occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on nonessential amino acids as substr...




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