Pathways
Glutathione Metabolism in S. flexneri 301
Description:
Shigella is a Gram-negative, non-sporulating, facultative anaerobic bacterium that causes Dysentery or Shigellosis in man. Shigella is highly invasive in the colon and the rectum, and is able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. S. flexneri 2a strain, 301 has been recently sequenced (Ref.1). Glutathione metabolism in Shigella occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on nonessential amino acids as substrates. Glutathione i...
References:
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How Do the Virulence Factors of Shigella Work Together to Cause Disease?
Front Cell Infect Microbiol. 2017 Mar 24;7:64. doi: 10.3389/fcimb.2017.00064. -
Glutathionylspermidine in the modification of protein SH groups: the enzymology and its application to study protein glutathionylation.
Molecules. 2015 Jan 15;20(1):1452-74. doi: 10.3390/molecules20011452. -
Bacterial Gamma-Glutamyl Transpeptidase, an Emerging Biocatalyst: Insights Into Structure-Function Relationship and Its Biotechnological Applications.
Front Microbiol. 2021 Apr 9;12:641251. doi: 10.3389/fmicb.2021.641251. -
"Phylogenetic and evolutionary analysis of functional divergence among Gamma glutamyl transpeptidase (GGT) subfamilies".
Free Radic Biol Med. 2004 Jun 15; 36(12):1481-95
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