Pathways
Glutathione Metabolism in D. melanogaster
Description:
Glutathione(Gsh) is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one of the most...
References:
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Emerging regulatory paradigms in glutathione metabolism.
Adv Cancer Res. 2014;122:69-101. doi: 10.1016/B978-0-12-420117-0.00002-5. Review. -
The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo.
J Biol Chem. 2003 Nov 21;278(47):46369-77. Epub 2003 Sep 3. -
Aging alters circadian regulation of redox in Drosophila.
Front Genet. 2015 Mar 9;6:83. doi: 10.3389/fgene.2015.00083. eCollection 2015. -
Modulation of signaling mechanisms in the heart by thioredoxin 1.
Free Radic Biol Med. 2017 Aug;109:125-131. doi: 10.1016/j.freeradbiomed.2016.12.020. Epub 2016 Dec 16. Review.
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