Pathways
Glutathione Metabolism in B. melitensis
Description:
Brucella is a Gram-negative aerobic pathogen that is distringuished from most other pathogens because it does not have "obvious virulence factors" like capsules, fimbriae, flagella, exotoxins, exproteases, or other exoenzymes, cytolysins, resistance forms, antigenic variation, plamids, or lysogenic phages (Ref.1). Brucella sp. causes a "zoonotic disease endemic in many areas of the world, characterized by chronic infections in animals leading to abortion and infertility, and a systemic, febril...
References:
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When the Going Gets Rough: The Significance of Brucella Lipopolysaccharide Phenotype in Host-Pathogen Interactions.
Front Microbiol. 2021 Jul 15;12:713157. doi: 10.3389/fmicb.2021.713157. -
Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens.
PLoS Negl Trop Dis. 2010 May 4;4(5):e673. doi: 10.1371/journal.pntd.0000673. -
The genome of Brucella melitensis.
Vet Microbiol. 2002 Dec 20; 90(1-4):587-92 -
Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease.
Int J Mol Sci. 2020 Oct 30;21(21):8113. doi: 10.3390/ijms21218113.
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