Pathways
Glutathione Metabolism in Z. mobilis
Description:
Zymomonas mobilis is an ethanologenic microorganism used for the production of fuel ethanol (Ref.1). Glutathione metabolism in Z. mobilis involves both the synthesis of Glutathione and its catabolism. Glutathione is a small molecule found in almost every cell. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which Glutathione can be made depends on the availability of Cysteine, which is relatively scarc...
References:
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Elucidation of Zymomonas mobilis physiology and stress responses by quantitative proteomics and transcriptomics.
Front Microbiol. 2014 May 22;5:246. doi: 10.3389/fmicb.2014.00246. -
NADPH-generating systems in bacteria and archaea.
Front Microbiol. 2015 Jul 29;6:742. doi: 10.3389/fmicb.2015.00742. -
Glutathione homeostasis and functions: potential targets for medical interventions.
J Amino Acids. 2012;2012:736837. doi: 10.1155/2012/736837. Epub 2012 Feb 28. -
High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.
Clin Chim Acta. 2004 Nov; 349(1-2):45-52.
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