Pathways
Glutathione Metabolism in R. norvegicus
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. The tripeptide Glutathione is part of an integrated antioxidant system that protects cells and tissues from oxidative damage. Oxidative stress can result from exposure to exc...
References:
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Age-related changes in the activity of antioxidant and redox enzymes in rats.
Mol Cells. 2003 Dec 31; 16(3):278-84. -
Gonadotropin regulation of glutathione synthesis in the rat ovary.
Reprod Toxicol. 2001 Sep-Oct; 15(5):495-504. -
Down-regulation of gamma-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging.
J Neurosci Res. 2002 May 1; 68(3):344-51. -
[Gamma Glutamyltransferase]
Nippon Rinsho. 1995 May; 53(5):1162-7.
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