Pathways
Glutathione Metabolism in Y. pestis CO92
Description:
Yersinia sp. is responsible for disease syndromes ranging from gastroenteritis to plague. Y. pestis is categorized into three subtypes or biovars; Antiqua, Mediaevalis, and Orientalis, each associated with a major pandemic. Y. pestis strain CO92 belongs to biovar Orientalis that are responsible for the current pandemic (modern plague). Glutathione is a tripeptide present in Yersinia sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells....
References:
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Molecular history of plague.
Clin Microbiol Infect. 2016 Nov;22(11):911-915. doi: 10.1016/j.cmi.2016.08.031. Epub 2016 Sep 8. -
Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight.
J Biol Chem. 2017 Sep 29;292(39):16360-16367. doi: 10.1074/jbc.M117.805028. Epub 2017 Aug 22. -
Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways.
Nat Chem Biol. 2011 Feb;7(2):101-5. doi: 10.1038/nchembio.499. Epub 2010 Dec 26. -
Glutathione reductase is essential for host defense against bacterial infection.
Free Radic Biol Med. 2013 Aug;61:320-32. doi: 10.1016/j.freeradbiomed.2013.04.015. Epub 2013 Apr 24.
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