Pathways
Glutathione Metabolism in S. pombe
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It has been assigned several cellular functions, including protection against oxidative damage, maintenance of a reducing cellular thiol-disulfide balance, electron donation for a number of enzymes, protection of protein sulfhydryls from irreversible oxidation, and detoxification of fore...
References:
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Site directed mutagenesis of Schizosaccharomyces pombe glutathione synthetase produces an enzyme with homoglutathione synthetase activity.
PLoS One. 2012;7(10):e46580. doi: 10.1371/journal.pone.0046580. Epub 2012 Oct 16. -
An overview on glutathione in Saccharomyces versus non-conventional yeasts.
FEMS Yeast Res. 2002 Aug; 2(3):295-305. -
The Schizosaccharomyces pombe gene encoding gamma-glutamyl transpeptidase I is regulated by non-fermentable carbon sources and nitrogen starvation.
J Microbiol. 2005 Feb; 43(1):44-8. -
Large conformational changes in the catalytic cycle of glutathione synthase.
Structure (Camb). 2002 Dec; 10(12):1669-76
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