Pathways
Glutathione Metabolism in H. sapiens
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one of the most hi...
References:
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Glutathione S-conjugates as prodrugs to target drug-resistant tumors. PJ.
Front Pharmacol. 2014 Aug 11;5:181. doi: 10.3389/fphar.2014.00181. eCollection 2014. Review. -
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Clin Toxicol (Phila). 2013 Nov;51(9):817-27. doi: 10.3109/15563650.2013.844822. Epub 2013 Oct 11. Review. -
Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.
J Biol Chem. 2003 Oct 10;278(41):39794-800. Epub 2003 Jul 29 -
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):601-20. Epub 2006 Mar 12. Review.
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