Pathways
Glutathione Metabolism in A. tumefaciens C58 UWash-Dupont
Description:
Agrobacterium tumefaciens C58 (UWash/Dupont) is a Gram-negative, non-sporing, motile, rod-shaped bacterium. It is a plant pathogen capable of transferring a defined segment of DNA to a host plant replacing the transferred tumor-inducing genes with exogenous DNA generating a gall tumor. A. tumefaciens strain C58 has an unusual structure consisting of one circular and one linear chromosome (Ref.1). Glutathione metabolism was largely depicted by the γ‐glutamyl cycle proposed in 1970. However it lacked k...
References:
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Linear chromosome-generating system of Agrobacterium tumefaciens C58: protelomerase generates and protects hairpin ends.
J Biol Chem. 2012 Jul 20;287(30):25551-63. doi: 10.1074/jbc.M112.369488. Epub 2012 May 10. -
Glutathione Degradation.
Antioxid Redox Signal. 2017 Nov 20;27(15):1200-1216. doi: 10.1089/ars.2017.7136. Epub 2017 Jun 26. -
The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle.
IUBMB Life. 2018 Jul;70(7):585-592. doi: 10.1002/iub.1756. Epub 2018 Apr 17. -
Bacterial γ-glutamyltranspeptidases, physiological function, structure, catalytic mechanism and application.
Proc Jpn Acad Ser B Phys Biol Sci. 2020;96(9):440-469. doi: 10.2183/pjab.96.033.10).
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