Pathways
Glutathione Metabolism in S. typhi CT18
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. I...
References:
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Current status and emerging role of glutathione in food grade lactic acid bacteria.
Microb Cell Fact. 2012 Aug 25;11:114. doi: 10.1186/1475-2859-11-114. -
Host-pathogen interaction in invasive Salmonellosis.
PLoS Pathog. 2012;8(10):e1002933. doi: 10.1371/journal.ppat.1002933. Epub 2012 Oct 4. -
The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle.
IUBMB Life. 2018 Jul;70(7):585-592. doi: 10.1002/iub.1756. Epub 2018 Apr 17. -
Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes.
Biochim Biophys Acta. 2013 May;1830(5):3217-66. doi: 10.1016/j.bbagen.2012.09.018. Epub 2012 Oct 2.
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