Pathways
Glutathione Metabolism in S. typhimurium LT2
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. F...
References:
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Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants.
Infect Immun. 2018 Jul 23;86(8):e00079-18. doi: 10.1128/IAI.00079-18. -
Glutathione homeostasis and functions: potential targets for medical interventions.
J Amino Acids. 2012;2012:736837. doi: 10.1155/2012/736837. Epub 2012 Feb 28. -
Glutathione: a review on biotechnological production.
Appl Microbiol Biotechnol. 2004 Dec;66(3):233-42. doi: 10.1007/s00253-004-1751-y. -
Glutathione reductase is essential for host defense against bacterial infection.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23.
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