Pathways
Glutathione Metabolism
Description:
Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It is composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one of the most highly concentrated intracell...
References:
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Regulation of glutathione synthesis.
Mol Aspects Med. 2009 Feb-Apr;30(1-2):42-59. doi: 10.1016/j.mam.2008.05.005. Epub 2008 Jun 14. Review. -
A mathematical model of glutathione metabolism.
Theor Biol Med Model. 2008 Apr 28;5:8. doi: 10.1186/1742-4682-5-8. -
Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease.
Clin Chim Acta. 2018 Jan;476:130-138. doi: 10.1016/j.cca.2017.11.026. Epub 2017 Nov 23. Review. -
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
J Biol Chem. 2008 Aug 8;283(32):22031-42. doi: 10.1074/jbc.M803623200. Epub 2008 May 30. Erratum in: J Biol Chem. 2008 Nov 14;283(46):32152.
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