Pathways
Glycine and Serine Metabolism in R. conorii
Description:
R. conorii (Rickettsia conorii) causes Mediterranean Spotted Fever in humans, which is transmitted by brown dog ticks. Rickettsia are obligate intracellular bacteria normally living in arthropod cells. Rickettsia are true bacteria, small coccobacilli that are normally stained with Giemsa and poorly by the Gram stain. Its cell wall morphology is that of a Gram-negative bacillus. Phylogenetically R. conorii is a member of the Alpha-subgroup of Proteobacteria (Ref.1). The bacterium is close...
References:
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Mediterranean Spotted Fever: Current Knowledge and Recent Advances.
Trop Med Infect Dis. 2021 Sep 24;6(4):172. doi: 10.3390/tropicalmed6040172. -
The relationship between spotted fever group Rickettsiae and ixodid ticks.
Vet Res. 2009 Mar-Apr;40(2):34. doi: 10.1051/vetres/2009017. Epub 2009 Apr 10. -
A Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Trigger Differential Proteome Signatures in Macrophages.
Front Cell Infect Microbiol. 2019 Mar 6;9:43. doi: 10.3389/fcimb.2019.00043. -
The complexity of the serine glycine one-carbon pathway in cancer.
J Cell Biol. 2020 Jan 6;219(1):e201907022. doi: 10.1083/jcb.201907022.
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