Pathways
Glycine, Serine and Threonine Metabolism in C. albicans
Description:
Like many bacteria, yeast species can form biofilms on several surfaces. C. albicans (Candida albicans) colonizes in the surfaces of catheters, prostheses, and epithelia, forming biofilms that are extremely resistant to anti-fungal drugs. The protein Gcn4 (Transcriptional Activator Gcn4), a regulator of amino acid metabolism, is required for normal biofilm growth. The biochemical mechanisms including activation of the sulfur-amino acid biosynthesis pathway is a feature of C. albicans biofilms. For s...
References:
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Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns.
Eukaryot. Cell. 2004 Apr;3(2):536-45. -
Characterization of the aspartate kinase from Saccharomyces cerevisiae and of its interaction with threonine.
Biochem. Biophys. Res. Commun. 2004 Aug 27;321(3):584-91. -
Glycine metabolism in Candida albicans: characterization of the serine hydroxymethyltransferase (SHM1, SHM2) and threonine aldolase (GLY1) genes.
Yeast. 2000 Jan 30;16(2):167-75. -
Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae.
J. Biol. Chem. 2004 Feb 20;279(8):7072-81.
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