Glycine, Serine and Threonine Metabolism in M. musculus

Description:

Glycine and Serine are two non-essential neurotrophic amino acids that play an essential role in neuronal development and function in M. musculus (Mus musculus). They share similar neurotrophic effects in promoting neuronal survival and differentiation of sensory ganglia, hippocampal neurons, and cerebellar Purkinje cells. In M. musculus, interplay between Glycine and Serine in a co-existence with L-Threonine represent a major metabolic crossroad that links several other biological pathways of im...

References:

Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats.
Scheer JB, Mackey AD, Gregory JF.
J. Nutr. 2005 Feb;135(2):233-8.
Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.
Li Q, Luo C, Löhr CV, Dashwood RH.
Hepatol Res. 2011 Aug;41(8):776-83. doi: 10.1111/j.1872-034X.2011.00827.x. Epub 2011 Jun 17.
Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.
Gupta S, Kühnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD.
FASEB J. 2009 Mar;23(3):883-93. doi: 10.1096/fj.08-120584. Epub 2008 Nov 5.
Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.
Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.
PLoS One. 2016 Aug 12;11(8):e0160521. doi: 10.1371/journal.pone.0160521. eCollection 2016. Erratum in: PLoS One. 2017 Aug 10;12 (8):e0183304.

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Pathways

Glycine, Serine and Threonine Metabolism in M. musculus

Description:

References:

Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats.

Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.

Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

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Pathways

Glycine, Serine and Threonine Metabolism in M. musculus

Description:

References:

Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats.

Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.

Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.

Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

Databases

Tools

Institutional License

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