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Pathways

Glycine, Serine and Threonine Metabolism in S. pombe

Description:

The metabolism of Glycine, Serine and Threonine is essential for the unicellular eukaryote S. pombe (Schizosaccharomyces pombe), as it uses L-Serine or L-Threonine as sole nitrogen source for its survival. During the metabolism of these amino acids, L-Threonine is generally synthesized from Pyruvate and L-Aspartate. The enzyme Threonine Ammonia Lyase/Threonine Dehydratase converts Pyruvate (from Pyruvate metab[...]

References:

  • A new mutation in the yeast aspartate kinase induces threonine accumulation in a temperature-regulated way.
    Velasco I, Arevalo-Rodriguez M, Marina P, Calderon IL.
    Yeast. 2005 Jan 30;22(2):99-110.
  • The genome sequence of Schizosaccharomyces pombe.
    Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Dusterhoft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sanchez M, del Rey F, Benito J, Dominguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P.
    Nature. 2002 Feb 21;415(6874):871-80.
  • Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae.
    Gelling CL, Piper MD, Hong SP, Kornfeld GD, Dawes IW.
    J. Biol. Chem. 2004 Feb 20;279(8):7072-81.
  • Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae.
    Albers E, Laize V, Blomberg A, Hohmann S, Gustafsson L.
    J. Biol. Chem. 2003 Mar 21;278(12):10264-72.
  • delta-aminolaevulinic acid modulates the resistance to fluconazole in a hem1 mutant of Saccharomyces cerevisiae.
    Kontoyiannis DP, May GS.
    J. Antimicrob. Chemother. 2000 Dec;46(6):1044-6.
  • Characterization of the aspartate kinase from Saccharomyces cerevisiae and of its interaction with threonine.
    Marina P, Martinez-Costa OH, Calderon IL, Aragon JJ.
    Biochem. Biophys. Res. Commun. 2004 Aug 27;321(3):584-91.
  • Evolution of different oligomeric glycyl-tRNA synthetases.
    Tang SN, Huang JF.
    FEBS. Lett. 2005 Feb 28;579(6):1441-5.
  • Genome evolution in yeasts.
    Dujon B, Sherman D, Fischer G, Durrens P, Casaregola S, Lafontaine I, De Montigny J, Marck C, Neuveglise C, Talla E, Goffard N, Frangeul L, Aigle M, Anthouard V, Babour A, Barbe V, Barnay S, Blanchin S, Beckerich JM, Beyne E, Bleykasten C, Boisrame A, Boyer J, Cattolico L, Confanioleri F, De Daruvar A, Despons L, Fabre E, Fairhead C, Ferry-Dumazet H, Groppi A, Hantraye F, Hennequin C, Jauniaux N, Joyet P, Kachouri R, Kerrest A, Koszul R, Lemaire M, Lesur I, Ma L, Muller H, Nicaud JM, Nikolski M, Oztas S, Ozier-Kalogeropoulos O, Pellenz S, Potier S, Richard GF, Straub ML, Suleau A, Swennen D, Tekaia F, Wesolowski-Louvel M, Westhof E, Wirth B, Zeniou-Meyer M, Zivanovic I, Bolotin-Fukuhara M, Thierry A, Bouchier C, Caudron B, Scarpelli C, Gaillardin C, Weissenbach J, Wincker P, Souciet JL.
    Nature. 2004 Jul 1;430(6995):35-44.
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