Pathways
Glycine, Serine and Threonine Metabolism
Description:
Organisms vary widely in their ability to metabolize amino acids. Based on metabolic requirements amino acids are grouped as essential amino acids (that must be provided in as nutrient) and non-essential amino acids (biosynthesized in adequate amounts). Except for Glycine, all amino acids occur in two possible optical isomers, called D and L. Because of the two hydrogen atoms at the Alpha-carbon, Glycine is not optically active. The L-amino acids represent the vast majority of amino acids found in proteins, whereas, D-amino a...
References:
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Functional amino acids in growth, reproduction, and health.
AdvNutr. 2010 Nov;1(1):31-7. -
Dietary essentiality of "nutritionally non-essential amino acids" for animals and humans.
ExpBiol Med (Maywood). 2015 Aug;240(8):997-1007. Epub 2015 Jun 2. -
Serine, glycine and one-carbon units: cancer metabolism in full circle.
Nat Rev Cancer. 2013 Aug;13(8):572-83. Epub 2013 Jul 4. -
New Insights into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems.
Front Microbiol. 2018 Apr 6;9:683.
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