Pathways
GPCR Pathway
Description:
GPCRs (Guanine Nucleotide Binding–Protein Coupled Receptors) comprise large and diverse gene families in fungi, plants, and the animal kingdom. Also termed serpentine receptors, GPCRs are polytopic membrane proteins that share a common structure with seven transmembrane segments, but sequence similarity is minimal among the most distant GPCRs. Their principal function is to transmit information about the extracellular environment to the interior of the cell, and they do this by interacting with the G-proteins. GPCRs rec...
References:
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Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach.
Cancer Genomics Proteomics. 2012 Jan;9(1):37-50. Review. -
G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.
Circ Res. 2011 Jul 8;109(2):217-30. doi: 10.1161/CIRCRESAHA.110.231225. Review. -
GPCR: G protein complexes--the fundamental signaling assembly.
Amino Acids. 2013 Dec;45(6):1303-14. doi: 10.1007/s00726-013-1593-y. Epub 2013 Sep 20. Review. -
Gq-Coupled Receptors in Autoimmunity.
J Immunol Res. 2016;2016:3969023. doi: 10.1155/2016/3969023. Epub 2016 Jan 17. Review.
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