Granzyme-B Pathway

Description:

CTLs (Cytotoxic T Lymphocytes) and NK (Natural Killer) cells are the key immune effectors that eradicate infected cells or tumors. To destroy these targets, CTLs and NK cells mostly use the granule exocytosis pathway, which releases perforin and Granzymes from cytolytic granules into the immunological synapse formed with the target. Granzyme-A and Granzyme-B, the most abundant Granzymes, are delivered to the target cell cytosol through perforin and independently induce cell death. Granzyme-B enters the target-cell cytosol ...

References:

Granzyme B-induced apoptosis in cancer cells and its regulation (review).
Rousalova I, Krepela E.
Int J Oncol. 2010 Dec;37(6):1361-78. Review.
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
Boivin WA, Cooper DM, Hiebert PR, Granville DJ.
Lab Invest. 2009 Nov;89(11):1195-220. doi: 10.1038/labinvest.2009.91. Epub 2009 Sep 21. Review.
Death by a thousand cuts: granzyme pathways of programmed cell death.
Chowdhury D, Lieberman J.
Annu Rev Immunol. 2008;26:389-420. doi: 10.1146/annurev.immunol.26.021607.090404. Review.
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.
Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, De Rosa SC.
J Leukoc Biol. 2009 Jan;85(1):88-97. doi: 10.1189/jlb.0208107. Epub 2008 Oct 10.

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Pathways

Granzyme-B Pathway

Description:

References:

Granzyme B-induced apoptosis in cancer cells and its regulation (review).

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

Death by a thousand cuts: granzyme pathways of programmed cell death.

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.

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Pathways

Granzyme-B Pathway

Description:

References:

Granzyme B-induced apoptosis in cancer cells and its regulation (review).

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

Death by a thousand cuts: granzyme pathways of programmed cell death.

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.

Databases

Tools

Institutional License

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