Granzyme-A Pathway

Description:

CTLs (Cytotoxic T Lymphocytes) and NK (Natural Killer) cells are the key immune effectors that eradicate infected cells or tumors. To destroy these targets, CTLs and NK cells mostly use the granule exocytosis pathway, which releases perforin and Granzymes from cytolytic granules into the immunological synapse formed with the target. Granzyme-A and Granzyme-B, the most abundant Granzymes, are delivered to the target cell cytosol through perforin and independently induce cell death. The tryptase Granzyme-A activates cell dea...

References:

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J.
Nat Immunol. 2003 Feb;4(2):145-53.
Granzyme A activates another way to die.
Lieberman J.
Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. Review.
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.
Chaitanya GV, Steven AJ, Babu PP.
Cell Commun Signal. 2010 Dec 22;8:31. doi: 10.1186/1478-811X-8-31.
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.
Zhu P, Martinvalet D, Chowdhury D, Zhang D, Schlesinger A, Lieberman J.
Blood. 2009 Aug 6;114(6):1205-16. doi: 10.1182/blood-2008-12-195768. Epub 2009 Jun 8.

You can view details of this pathway by subscribing:

Subscribe Now

Pathways

Granzyme-A Pathway

Description:

References:

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

Granzyme A activates another way to die.

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

Databases

Tools

Institutional License

Pathways

Granzyme-A Pathway

Description:

References:

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

Granzyme A activates another way to die.

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

Databases

Tools

Institutional License

Log In