Pathways
Granzyme Pathway
Description:
Killer lymphocytes are key players in the effector arm of the immune response that eliminate cells infected with intracellular pathogens and transformed tumor cells. Killer cells in both adaptive and innate immunity-T cells (CTLS) and natural killer (NK) cells, respectively, use the same basic mechanisms for destroying their targets, although they are triggered by distinct receptors and the expression of cytotoxic granules is constitutive in NK cells, but regulated in T cells. Release of the contents of cytotoxic granules ...
References:
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The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal.
Nat Rev Immunol. 2003 May;3(5):361-70. Review. -
Granzyme A activates another way to die.
Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. Review. -
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.
Blood. 2009 Aug 6;114(6):1205-16. doi: 10.1182/blood-2008-12-195768. Epub 2009 Jun 8. -
Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing.
Cell Mol Immunol. 2012 Jan;9(1):5-6. doi: 10.1038/cmi.2011.45. Epub 2011 Sep 19. No abstract available.
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