Pathways
Growth Hormone Signaling
Description:
Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/IGF1 axis (in somatopause). Physical changes during a...
References:
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The role of androgens and estrogens on healthy aging and longevity.
J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1140-52. doi: 10.1093/gerona/gls068. Epub 2012 Mar 26. Review. -
GH/IGF-1 Signaling and Current Knowledge of Epigenetics; a Review and Considerations on Possible Therapeutic Options.
Int J Mol Sci. 2017 Oct 5;18(10). pii: E1624. doi: 10.3390/ijms18101624. Review. -
Adult growth hormone deficiency - benefits, side effects, and risks of growth hormone replacement.
Front Endocrinol (Lausanne). 2013 Jun 4;4:64. doi: 10.3389/fendo.2013.00064. eCollection 2013. -
Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction.
Int J Mol Sci. 2018 Jun 22;19(7). pii: E1843. doi: 10.3390/ijms19071843. Review.
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