Pathways
GSK3 Signaling
Description:
GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes. Identified originally as a regulator of glycogen metabolism, GSK3 acts as a downstream regulatory switch for numerous signaling pathways, including cellular responses to WNT, Growth Factors, Insulin, RTK (Receptor Tyrosine Kinases), Hedgehog pathways, and GPCR (G-Protein-Coupled Receptors) and is involved in a wide range of signal transduction cascades involving cellular processes, ranging from...
References:
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The Role of GSK3 in Presynaptic Function.
Int J Alzheimers Dis. 2011 Mar 14;2011:263673. doi: 10.4061/2011/263673. -
Deconstructing GSK-3: The Fine Regulation of Its Activity.
Int J Alzheimers Dis. 2011;2011:479249. doi: 10.4061/2011/479249. Epub 2011 Apr 28. -
What Are the bona fide GSK3 Substrates?
Int J Alzheimers Dis. 2011;2011:505607. doi: 10.4061/2011/505607. Epub 2011 May 18. -
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.
Cancer Lett. 2009 Jan 18;273(2):194-200. doi: 10.1016/j.canlet.2008.05.045. Epub 2008 Jul 7. Review.
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