As an axon grows, the growth cone at its advancing edge encounters specific ‘choice points’ at which guidance cues steer specific axons towards their appropriate destinations. Such cues may attract a subset of axons towards a given domain, repel axons from inappropriate target regions or simply provide a permissive substrate for axonal outgrowth. There are many different ways in which a guidance signal might intervene to steer the growth cone. For example, a guidance cue might promote the initiation, extension, st...
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