Pathways
HBV Replication Cycle
Description:
HBV (Hepatitis-B Virus) belongs to a family of closely related DNA viruses called the Hepadnaviruses. Included in this family are the WHV (Woodchuck Hepatitis Virus), the DHBV (Duck Hepatitis-B Virus) and several other avian and mammalian variants. Hepadnaviruses have a strong preference for infecting liver cells, but small amounts of hepadnaviral DNA can be found in kidney, pancreas, and mononuclear cells. However, infection at these sites is not linked to extra hepatic disease (Ref.1). The HBV nucleocapsid contains a relati...
References:
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Avian and Mammalian hepadnaviruses have distinct transcription factor requirements for viral replication.
J Virol. 2002 Aug; 76(15):7468-72. -
Regulation of Hepatitis-B virus replication by the ras-mitogen-activated protein kinase signaling pathway.
J Virol. 2003 Jul; 77(14):7707-12. -
The discovery of the Hepatitis-B virus and the invention of the vaccine: a scientific memoir.
J Gastroenterol Hepatol. 2002 Dec; 17 Suppl: S502-3. -
Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids
Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9020-5. Epub 2005 Jun 10.
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