Pathways
HCV Life Cycle
Description:
Hepatitis-C Virus (HCV) belongs to the Flaviviridae family and is the leading cause of chronic liver disease globally. It is estimated to infect about 170 million people around the world (WHO, 1997). Chronic HCV infection frequently leads to liver fibrosis and cirrhosis, and is associated with the occurrence of hepatocellular carcinoma. Acute infection occurs in only a few patients. In most cases the virus results in chronic infection taking 10–20 years before the emergence of liver disease, which is often accompanied b...
References:
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Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties.
Curr Top Microbiol Immunol. 2000; 242:55-84 -
Unravelling hepatitis C virus replication from genome to function.
Nature 2005 Aug 18; 436(7053):933-8. -
Alternate translation occurs within the core coding region of the hepatitis C viral genome.
J Biol Chem. 2002 May 17; 277(20):17713-21. Epub 2002 Mar 7. -
Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame.
RNA. 2001 May; 7(5):710-21.
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