The Hh (Hedgehog) proteins are evolutionarily conserved signaling molecules that control the normal growth and patterning of diverse animals including Drosophila and humans. In flies, Hh is required for multiple developmental processes such as embryonic segment patterning, eye and appendage development. A single Drosophila Hedgehog gene has three mammalian counterparts: SHh (Sonic Hedgehog), IHh (Indian Hedgehog), and DHh (Desert Hedgehog). The Hh proteins are extracellular signaling mole...
Genes Dev. 2001 Dec 1;15(23):3059-87.
J. Biol. Chem. 2006 Aug 30.
Bosn J Basic Med Sci. 2018 Feb 20;18(1):8-20. doi: 10.17305/bjbms.2018.2756. Review.
J Biol Chem. 2015 Feb 6;290(6):3500-7. doi: 10.1074/jbc.R114.617936. Epub 2014 Dec 17. Review.
You can view details of this pathway by subscribing: