Pathways
Hedgehog Signaling in Drosophila
Description:
The Hh (Hedgehog) proteins are evolutionarily conserved signaling molecules that control the normal growth and patterning of diverse animals including Drosophila and humans. In flies, Hh is required for multiple developmental processes such as embryonic segment patterning, eye and appendage development. A single Drosophila Hedgehog gene has three mammalian counterparts: SHh (Sonic Hedgehog), IHh (Indian Hedgehog), and DHh (Desert Hedgehog). The Hh proteins are extracellular signaling mole...
References:
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Hedgehog signaling in animal development: paradigms and principles.
Genes Dev. 2001 Dec 1;15(23):3059-87. -
Molecular pathways regulating pro- migratory effects of hedgehog signaling.
J. Biol. Chem. 2006 Aug 30. -
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Bosn J Basic Med Sci. 2018 Feb 20;18(1):8-20. doi: 10.17305/bjbms.2018.2756. Review. -
Smoothened goes molecular: new pieces in the hedgehog signaling puzzle.
J Biol Chem. 2015 Feb 6;290(6):3500-7. doi: 10.1074/jbc.R114.617936. Epub 2014 Dec 17. Review.
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