Pathways
Hedgehog Signaling in Mammals
Description:
Controlled cell proliferation is a predominant theme in normal embryonic and post-embryonic development, and, in many instances, cell-type specification and cell proliferation are intimately coupled. Several secreted intercellular signaling proteins that behave as morphogens during pattern formation are also implicated in the regulation of the cell cycle. Hedgehogs (Hhs) are one such class of morphogens that regulate an enormous variety of developmental events in the fly and vertebrate embryo and plays a central role in sever...
References:
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The Hedgehog signal transduction network.
Sci Signal. 2012 Oct 16;5(246):re6. doi: 10.1126/scisignal.2002906. Review. -
The legacy of Drosophila imaginal discs.
Chromosoma. 2016 Sep;125(4):573-92. doi: 10.1007/s00412-016-0595-4. Epub 2016 May 7. Review. -
Choudhry Z, Rikani AA, Choudhry AM, Tariq S, Zakaria F, Asghar MW, Sarfraz MK, Haider K, Shafiq AA, Mobassarah NJ.
Ann Neurosci. 2014 Jan;21(1):28-31. doi: 10.5214/ans.0972.7531.210109. Review. -
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.
Dev Cell. 2011 Jun 14;20(6):788-801. doi: 10.1016/j.devcel.2011.04.017.
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