Pathways
Hematopoiesis from Multipotent Stem Cell
Description:
Hematopoiesis is the process that generates blood cells of all lineages (Ref.1). The process of generation of blood cells begins in the early embryo and continues throughout life. Every day, billions of new blood cells are produced in the body, each one derived from a HSC (Hematopoietic Stem Cell). Because most mature blood stem cells have a limited life span, the ability of HSCs to perpetuate themselves through self-renewal and generate new blood cells for the lifetime of an organism is critical to sustaining life. Hematopoieti...
References:
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Lineage-specific hematopoietic growth factors.
N Engl J Med. 2006 May 11; 354(19):2034-45. Review. No abstract available. -
Cytokine receptors and hematopoietic differentiation.
Oncogene. 2007 Oct 15; 26(47):6715-23. Review. -
Regulation of hematopoietic stem cell self-renewal.
Recent Prog Horm Res. 2003; 58:283-95. Review. -
Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.
Am J Pathol. 2006 Aug; 169(2):338-46. Erratum in: Am J Pathol. 2006 Nov; 169(5):1899.
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