Pathways
Hematopoiesis from Pluripotent Stem Cell
Description:
Hematopoietic Stem Cells (HSCs) have the property of self-renewal and through cell division and differentiation, form populations of progenitor cells which are committed to the main marrow cell lines; Erythroid, Granulocytic and Monocytic, Megakaryocytic and Lymphocytic. The earlier progenitor cells are multipotent but, as division and differentiation proceed, later progenitors are formed that are committed to three, two or one cell line (Ref.1 & 2). In the strictest sense depending on potency (i.e., the capacity to differentiat...
References:
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Early decisions in lymphoid development.
Curr Opin Immunol. 2007 Apr; 19(2):123-8. Epub 2007 Feb 15. Review. -
Regulation of hematopoietic stem cell self-renewal.
Recent Prog Horm Res. 2003; 58:283-95. Review. -
Signal transduction pathways that contribute to myeloid differentiation.
Leukemia. 2007 Jul; 21(7):1363-77. Epub 2007 Apr 19. Review. -
Lineage-specific hematopoietic growth factors.
N Engl J Med. 2006 May 11; 354(19):2034-45. Review. No abstract available.
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