Hepatic ABC Transporters

Description:

ABC (ATP-binding cassette) transporters are a large superfamily of integral membrane proteins involved in the cellular export or import of a wide variety of different substances, including ions, lipids, cyclic nucleotides, peptides, and proteins. ABC transporters are systemically classified into eight subfamilies by sequence similarity, i.e., ABCA (ABC1), ABCB (MDR/TAP), ABCC (MRP/CFTR), ABCD (ALD), ABCE (RNAseLI/OABP), ABCF (GCN20), ABCG (White) and ANSA subclass. In general, the transmembrane part of ABC transporters con...

References:

Structure and mechanism of ABC transporters.
Wilkens S.
F1000Prime Rep. 2015 Feb 3;7:14. doi: 10.12703/P7-14. eCollection 2015. Review.
Drug resistance mediated by ABC transporters
Yoshikawa M, Ito A, Ishikawa T, Ikegami Y.
Gan To Kagaku Ryoho. 2004 Jan; 31(1):1-6.
Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.
Coleman JA, Quazi F, Molday RS.
Biochim Biophys Acta. 2013 Mar;1831(3):555-74. doi: 10.1016/j.bbalip.2012.10.006. Epub 2012 Oct 26. Review.
ABC transporters and inhibitors: new targets, new agents.
Leonard GD, Polgar O, Bates SE.
Curr Opin Investig Drugs. 2002 Nov; 3(11):1652-9.

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Pathways

Hepatic ABC Transporters

Description:

References:

Structure and mechanism of ABC transporters.

Drug resistance mediated by ABC transporters

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.

ABC transporters and inhibitors: new targets, new agents.

Databases

Tools

Institutional License

Pathways

Hepatic ABC Transporters

Description:

References:

Structure and mechanism of ABC transporters.

Drug resistance mediated by ABC transporters

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.

ABC transporters and inhibitors: new targets, new agents.

Databases

Tools

Institutional License

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