Pathways
HIF1Alpha Pathway
Description:
The cellular response to O2 (oxygen) is a central process in animal cells and figures prominently in the pathophysiology of several diseases, including cancer, cardiovascular disease, and stroke. This process is coordinated by the HIF (Hypoxia-Inducible Factor) and its regulator, the pVHL (Von Hippel-Lindau tumor suppressor protein). HIF1 is a basic helix-loop-helix transcription factor that transactivates genes encoding proteins that participate in homeostatic responses to hypoxia. It induces expression of proteins controlli...
References:
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Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?
Mediators Inflamm. 2015;2015:584758. doi: 10.1155/2015/584758. Epub 2015 Sep 27. Review. -
Silencing of hypoxia-inducible factor-1ß induces anti-tumor effects in hepatoma cell lines under tumor hypoxia.
PLoS One. 2014 Jul 28;9(7):e103304. doi: 10.1371/journal.pone.0103304. eCollection 2014. -
Inflammation and hypoxia in the kidney: friends or foes?
Kidney Int. 2015 Aug;88(2):213-5. doi: 10.1038/ki.2015.89. -
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
Structure. 2017 Jun 6;25(6):901-911.e3. doi: 10.1016/j.str.2017.04.009.
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